Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

Background: Intermediate filament proteins that construct the nuclear lamina protein lamin cell including A / C is encoded by the gene LMNA, and is involved in fundamental processes such as nuclear structure, gene expression and signal transduction. LMNA mutations predominantly affect the mesoderm-derived cell lineages in diseases collectively referred to as laminopathies which include dilated cardiomyopathy with conduction defects, various forms of muscular dystrophy and premature aging syndromes as Hutchinson-Gilford Progeria Syndrome. At present, our understanding of the molecular mechanisms that regulate tissue-specific manifestations of laminopathies still limited.


Methods: To gain more insight into the molecular mechanisms of a novel splice-site mutations in LMNA (c.357-2A> G) in a family affected by heart disease, we do deep RNA sequencing and analysis for the nine lines derived fibroblast samples three patients with cardiomyopathy, three unaffected family members, and three unrelated individuals not affected. We validated our findings by the study of quantitative PCR and protein.


Results: We identified eight genes were significantly differentially expressed between fibroblasts mutant and non-mutant, which included downregulated factor insulin growth factor binding protein 5 (IGFBP5) in patient samples. ERK pathway analysis indicates involvement / MAPK signaling pathways consistent with previous studies. We found no significant differences in gene expression of lamin A / C and B-type lamins between groups. In the mutant fibroblasts, RNA-seq confirmed that only LMNA predominantly expressed wild-type allele, and Western blot showed normal levels of the protein lamin A / C


Conclusion: IGFBP5 can contribute in maintaining homeostasis pathway signaling, which may cause the molecular and structural abnormalities is important in the network are not affected as fibroblasts. the mechanism of compensation of other nuclear membrane protein was not found. Our results also showed that only one copy of the wild allele kind enough to normal levels of the protein lamin A / C to maintain physiological functions in the cell type affected.

This indicates that the affected cell types such as heart tissue may be more sensitive to haploinsufficiency of lamin A / C. These results provide insight into the molecular mechanisms of diseases with a possible explanation for tissue specificity LMNA related dilated cardiomyopathy.

Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis
Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis

Genome-wide identification and expression-based transcriptome profiles of Wnt gene family in Ruditapes philippinarum

Wnt genes encode a set of conserved glycoprotein regulate early development, proliferation and differentiation of cells and tissue regeneration in metazoans. In some mollusks, knowledge of the Wnt gene family has been limited because of scarce resources genomic and transcriptomic. Ruditapes philippinarum is economically important shellfish with a variety of shell color patterns and the ability to regenerate its siphon.

To gain a greater understanding of the dynamics of the Wnt gene family evolution, we performed genome-wide identification and phylogenetic analysis of the Wnt gene family in R. philippinarum and four other mollusks. A total of 12 Wnt genes identified in the genome of R. philippinarum and dynamic patterns of gene conservation, loss and duplication of Wnt genes analyzed in mollusks and model organisms.

Polyclonal RWDD3 Antibody (C-Terminus)

APR02713G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RWDD3 (C-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal RWDD3 Antibody (N-Terminus)

APR02714G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RWDD3 (N-Terminus). This antibody is tested and proven to work in the following applications:

RWDD4A Antibody (Rabbit Polyclonal)

E308395b 100ug/200ul
EUR 275
Description: Available in various conjugation types.

RWDD1 Polyclonal Antibody

31688 100ul
EUR 439

RWDD1 Polyclonal Antibody

31688-100ul 100ul
EUR 302.4

RWDD1 Polyclonal Antibody

31688-50ul 50ul
EUR 224.4

RWDD1 Polyclonal Antibody

E99237 100ul
EUR 225
Description: Available in various conjugation types.

RWDD2A Polyclonal Antibody

A60754
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  • 100 µg
  • 20 ul
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RWDD3 Antibody

5407-002mg 0.02 mg
EUR 206.18
Description: RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases IκBeta sumoylation and stability. In addition, RWDD3 inhibits TNF-α-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of IκBeta increased stability. RSUME-enhanced sumoylation of IκBeta leads to the inhibition of NF-κBeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

RWDD3 Antibody

5407-01mg 0.1 mg
EUR 523.7
Description: RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases IκBeta sumoylation and stability. In addition, RWDD3 inhibits TNF-α-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of IκBeta increased stability. RSUME-enhanced sumoylation of IκBeta leads to the inhibition of NF-κBeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

RWDD3 Antibody

5409-002mg 0.02 mg
EUR 206.18
Description: RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases IκBeta sumoylation and stability. In addition, RWDD3 inhibits TNF-α-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of IκBeta increased stability. RSUME-enhanced sumoylation of IκBeta leads to the inhibition of NF-κBeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

RWDD3 Antibody

5409-01mg 0.1 mg
EUR 523.7
Description: RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases IκBeta sumoylation and stability. In addition, RWDD3 inhibits TNF-α-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of IκBeta increased stability. RSUME-enhanced sumoylation of IκBeta leads to the inhibition of NF-κBeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

RWDD3 Antibody

24973 100ul
EUR 479

RWDD3 Antibody

24973-100ul 100ul
EUR 468

RWDD3 Antibody

24974 100ul
EUR 479

RWDD3 Antibody

24974-100ul 100ul
EUR 468

RWDD3 Antibody

DF16015 100ul
EUR 420

RWDD3 Antibody

DF16015-100ul 100ul
EUR 280

RWDD3 Antibody

DF16015-200ul 200ul
EUR 350

RWDD3 Antibody

E308420 200ul
EUR 275
Description: Available in various conjugation types.

RWDD3 Antibody

GWB-MV585I 50ug Ask for price

RWDD1 Polyclonal Conjugated Antibody

C31688 100ul
EUR 476.4

RWDD2A Polyclonal Antibody, HRP Conjugated

A60757
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  • 100 µg
  • 50 ul
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RWDD2A Polyclonal Antibody, FITC Conjugated

A60756
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  • 100 µg
  • 50 ul
  • 100 ul

RWDD2A Polyclonal Antibody, Biotin Conjugated

A60755
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  • 100 µg
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anti- RWDD3 antibody

FNab07540 100µg
EUR 702
Description: Antibody raised against RWDD3

Rabbit Polyclonal AntibodyPC1 Rabbit Polyclonal Antibody

53940 100ul
EUR 439

Rabbit Polyclonal AntibodyPC4 Rabbit Polyclonal Antibody

54946 100ul
EUR 439

Rabbit Polyclonal Anti-BAG4 rabbit polyclonal antibody

TA351743 100 µl Ask for price

Rabbit Polyclonal Anti-LPP rabbit polyclonal antibody

TA351364 100 µl Ask for price

Rabbit Polyclonal Anti-TPR rabbit polyclonal antibody

TA351467 100 µl Ask for price

Rabbit Polyclonal Anti-RORA rabbit polyclonal antibody

TA351609 100 µl Ask for price

Rabbit Polyclonal Anti-SSX5 rabbit polyclonal antibody

TA351758 100 µl Ask for price

Rabbit Polyclonal Anti-TGM7 rabbit polyclonal antibody

TA351848 100 µl Ask for price

Rabbit Polyclonal Anti-NOX5 rabbit polyclonal antibody

TA350234 100 µl Ask for price

Rabbit Polyclonal Anti-SRPX rabbit polyclonal antibody

TA350419 100 µl Ask for price

Rabbit Polyclonal Anti-STX7 rabbit polyclonal antibody

TA350469 100 µl Ask for price

Rabbit Polyclonal Anti-STX8 rabbit polyclonal antibody

TA350470 100 µl Ask for price

Rabbit Polyclonal Anti-CERS3 rabbit polyclonal antibody

TA351342 100 µl Ask for price

Rabbit Polyclonal Anti-LLGL2 rabbit polyclonal antibody

TA351357 100 µl Ask for price

Rabbit Polyclonal Anti-PSMB8 rabbit polyclonal antibody

TA351358 100 µl Ask for price

Rabbit Polyclonal Anti-LONP1 rabbit polyclonal antibody

TA351359 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL2 rabbit polyclonal antibody

TA351360 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL3 rabbit polyclonal antibody

TA351362 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL4 rabbit polyclonal antibody

TA351363 100 µl Ask for price

Rabbit Polyclonal Anti-LZTS1 rabbit polyclonal antibody

TA351367 100 µl Ask for price

Rabbit Polyclonal Anti-MACC1 rabbit polyclonal antibody

TA351368 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD5 rabbit polyclonal antibody

TA351731 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV5 rabbit polyclonal antibody

TA351861 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV3 rabbit polyclonal antibody

TA351862 100 µl Ask for price

Rabbit Polyclonal Anti-SPARC rabbit polyclonal antibody

TA349441 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM3 rabbit polyclonal antibody

TA350251 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM4 rabbit polyclonal antibody

TA350252 100 µl Ask for price

Rabbit Polyclonal Anti-ROBO4 rabbit polyclonal antibody

TA350367 100 µl Ask for price

Rabbit Polyclonal Anti-RRAGA rabbit polyclonal antibody

TA350374 100 µl Ask for price

Rabbit Polyclonal Anti-SAMD7 rabbit polyclonal antibody

TA350388 100 µl Ask for price

Rabbit Polyclonal Anti-SEPP1 rabbit polyclonal antibody

TA350395 100 µl Ask for price

Rabbit Polyclonal Anti-SENP8 rabbit polyclonal antibody

TA350399 100 µl Ask for price

Rabbit Polyclonal Anti-SENP5 rabbit polyclonal antibody

TA350400 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD3 rabbit polyclonal antibody

TA350428 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD4 rabbit polyclonal antibody

TA350429 100 µl Ask for price

Rabbit Polyclonal Anti-SNAI3 rabbit polyclonal antibody

TA350430 100 µl Ask for price

Rabbit Polyclonal Anti-STX18 rabbit polyclonal antibody

TA350473 100 µl Ask for price

Rabbit Polyclonal Anti-STX11 rabbit polyclonal antibody

TA350476 100 µl Ask for price

Rabbit Polyclonal Anti-STX19 rabbit polyclonal antibody

TA350477 100 µl Ask for price

Rabbit Polyclonal Anti-TBX18 rabbit polyclonal antibody

TA350485 100 µl Ask for price

Rabbit Polyclonal Anti-TBX10 rabbit polyclonal antibody

TA350486 100 µl Ask for price

Rabbit Polyclonal Anti-EFNB3 rabbit polyclonal antibody

TA350660 100 µl Ask for price

Rabbit Polyclonal Anti-FOXG1 rabbit polyclonal antibody

TA350672 100 µl Ask for price

Rabbit Polyclonal Anti-LTB4R2 rabbit polyclonal antibody

TA351366 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT9 rabbit polyclonal antibody

TA351369 100 µl Ask for price

Rabbit Polyclonal Anti-MAGEB2 rabbit polyclonal antibody

TA351371 100 µl Ask for price

Rabbit Polyclonal Anti-SLC7A5 rabbit polyclonal antibody

TA351714 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT6 rabbit polyclonal antibody

TA351863 100 µl Ask for price

Rabbit Polyclonal Anti-PRSS50 rabbit polyclonal antibody

TA351865 100 µl Ask for price

Rabbit Polyclonal Anti-PTPMT1 rabbit polyclonal antibody

TA350308 100 µl Ask for price

Rabbit Polyclonal Anti-DHCR24 rabbit polyclonal antibody

TA350394 100 µl Ask for price

Rabbit Polyclonal Anti-SEMA4A rabbit polyclonal antibody

TA350396 100 µl Ask for price

Rabbit Polyclonal Anti-TRIM21 rabbit polyclonal antibody

TA350447 100 µl Ask for price

Rabbit Polyclonal Anti-STXBP4 rabbit polyclonal antibody

TA350474 100 µl Ask for price

Rabbit Polyclonal Anti-MAGEA11 rabbit polyclonal antibody

TA351370 100 µl Ask for price

Rabbit Polyclonal Anti-SLC16A9 rabbit polyclonal antibody

TA351677 100 µl Ask for price

Rabbit Polyclonal Anti-SLC24A6 rabbit polyclonal antibody

TA351684 100 µl Ask for price

Rabbit Polyclonal Anti-SLC17A1 rabbit polyclonal antibody

TA351718 100 µl Ask for price

Rabbit Polyclonal Anti-S100A14 rabbit polyclonal antibody

TA350383 100 µl Ask for price

Rabbit Polyclonal Anti-SH3KBP1 rabbit polyclonal antibody

TA350412 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB1 rabbit polyclonal antibody

TA350405 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB6 rabbit polyclonal antibody

TA350406 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB8 rabbit polyclonal antibody

TA350407 100 µl Ask for price

Rabbit Polyclonal Anti-SIGLEC12 rabbit polyclonal antibody

TA350415 100 µl Ask for price

Rabbit Polyclonal Anti-SLC25A26 rabbit polyclonal antibody

TA350422 100 µl Ask for price

Polyclonal AntibodyP3 Rabbit Polyclonal Antibody

ES6454-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP3 Rabbit Polyclonal Antibody

ES6454-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP1 Rabbit Polyclonal Antibody

ES11752-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP1 Rabbit Polyclonal Antibody

ES11752-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP5 Rabbit Polyclonal Antibody

ES4829-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP5 Rabbit Polyclonal Antibody

ES4829-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal AntibodyP2 Rabbit Polyclonal Antibody

ES10016-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP2 Rabbit Polyclonal Antibody

ES10016-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP4 Rabbit Polyclonal Antibody

ES10017-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal AntibodyP4 Rabbit Polyclonal Antibody

ES10017-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

ATM Rabbit Rabbit Polyclonal Antibody

ES8456-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Rabbit Polyclonal Antibody

ES8456-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Rabbit Polyclonal Antibody

ES8457-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATM Rabbit Rabbit Polyclonal Antibody

ES8457-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATM Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

VEGF Rabbit Rabbit Polyclonal Antibody

ES8453-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against VEGF Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

VEGF Rabbit Rabbit Polyclonal Antibody

ES8453-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against VEGF Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

CD10 Rabbit Rabbit Polyclonal Antibody

ES8454-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against CD10 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

CD10 Rabbit Rabbit Polyclonal Antibody

ES8454-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against CD10 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK1 Rabbit Rabbit Polyclonal Antibody

ES8562-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JAK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK1 Rabbit Rabbit Polyclonal Antibody

ES8562-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JAK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK2 Rabbit Rabbit Polyclonal Antibody

ES8563-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JAK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JAK2 Rabbit Rabbit Polyclonal Antibody

ES8563-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JAK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JNK2 Rabbit Rabbit Polyclonal Antibody

ES8564-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JNK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

JNK2 Rabbit Rabbit Polyclonal Antibody

ES8564-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JNK2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

JNK3 Rabbit Rabbit Polyclonal Antibody

ES8565-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against JNK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

JNK3 Rabbit Rabbit Polyclonal Antibody

ES8565-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against JNK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

MEK2 Rabbit Rabbit Polyclonal Antibody

ES8566-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against MEK2 Rabbit from Human. This antibody is tested and validated for WB, ELISA, IHC

MEK2 Rabbit Rabbit Polyclonal Antibody

ES8566-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against MEK2 Rabbit from Human. This antibody is tested and validated for WB, ELISA, IHC

MEK3 Rabbit Rabbit Polyclonal Antibody

ES8567-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against MEK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

MEK3 Rabbit Rabbit Polyclonal Antibody

ES8567-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against MEK3 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Nrf2 Rabbit Rabbit Polyclonal Antibody

ES8568-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Nrf2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Nrf2 Rabbit Rabbit Polyclonal Antibody

ES8568-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Nrf2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG5 Rabbit Rabbit Polyclonal Antibody

ES8572-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG5 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG5 Rabbit Rabbit Polyclonal Antibody

ES8572-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG5 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG7 Rabbit Rabbit Polyclonal Antibody

ES8573-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG7 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG7 Rabbit Rabbit Polyclonal Antibody

ES8573-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG7 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Rabbit Polyclonal Antibody

ES8578-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Rabbit Polyclonal Antibody

ES8578-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Rabbit Polyclonal Antibody

ES8579-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NBR1 Rabbit Rabbit Polyclonal Antibody

ES8579-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against NBR1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Gab1 Rabbit Rabbit Polyclonal Antibody

ES8582-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Gab1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

Gab1 Rabbit Rabbit Polyclonal Antibody

ES8582-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Gab1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ERK1 Rabbit Rabbit Polyclonal Antibody

ES8583-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ERK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ERK1 Rabbit Rabbit Polyclonal Antibody

ES8583-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ERK1 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NM23A Rabbit Rabbit Polyclonal Antibody

ES8455-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against NM23A Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

NM23A Rabbit Rabbit Polyclonal Antibody

ES8455-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against NM23A Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

HSC70 Rabbit Rabbit Polyclonal Antibody

ES8558-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against HSC70 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

HSC70 Rabbit Rabbit Polyclonal Antibody

ES8558-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against HSC70 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

HSP40 Rabbit Rabbit Polyclonal Antibody

ES8559-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against HSP40 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

HSP40 Rabbit Rabbit Polyclonal Antibody

ES8559-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against HSP40 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

ATG4a Rabbit Rabbit Polyclonal Antibody

ES8569-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG4a Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4a Rabbit Rabbit Polyclonal Antibody

ES8569-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG4a Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4b Rabbit Rabbit Polyclonal Antibody

ES8570-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG4b Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4b Rabbit Rabbit Polyclonal Antibody

ES8570-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG4b Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4c Rabbit Rabbit Polyclonal Antibody

ES8571-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG4c Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG4c Rabbit Rabbit Polyclonal Antibody

ES8571-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG4c Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG13 Rabbit Rabbit Polyclonal Antibody

ES8574-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG13 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG13 Rabbit Rabbit Polyclonal Antibody

ES8574-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG13 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG13 Rabbit Rabbit Polyclonal Antibody

ES8575-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG13 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG13 Rabbit Rabbit Polyclonal Antibody

ES8575-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG13 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

WIPI2 Rabbit Rabbit Polyclonal Antibody

ES8580-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against WIPI2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

WIPI2 Rabbit Rabbit Polyclonal Antibody

ES8580-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against WIPI2 Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

HSP90α Rabbit Rabbit Polyclonal Antibody

ES8560-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against HSP90? Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

HSP90α Rabbit Rabbit Polyclonal Antibody

ES8560-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against HSP90? Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG14L Rabbit Rabbit Polyclonal Antibody

ES8576-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ATG14L Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

ATG14L Rabbit Rabbit Polyclonal Antibody

ES8576-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ATG14L Rabbit from Human/Mouse/Rat. This antibody is tested and validated for IHC

IkB α Rabbit Rabbit Polyclonal Antibody

ES8561-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against IkB ? Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

IkB α Rabbit Rabbit Polyclonal Antibody

ES8561-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against IkB ? Rabbit from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

41701 Rabbit Polyclonal Antibody

E10G23595 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

hCG_2024410 Rabbit Polyclonal Antibody

E10G30899 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

44996 Rabbit Polyclonal Antibody

E10G31345 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

44986 Rabbit Polyclonal Antibody

E10G31451 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

45180 Rabbit Polyclonal Antibody

E10G31706 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

44994 Rabbit Polyclonal Antibody

E10G31789 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

45175 Rabbit Polyclonal Antibody

E10G32031 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

45181 Rabbit Polyclonal Antibody

E10G32185 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

45178 Rabbit Polyclonal Antibody

E10G32696 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

OsI_09476 Rabbit Polyclonal Antibody

E580441-A-SE 100ul
EUR 325
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

41701 Rabbit Polyclonal Antibody

E10G22867 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

41701 Rabbit Polyclonal Antibody

E10G22870 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TH Rabbit Polyclonal Antibody

53004 100ul
EUR 439

Rb Rabbit Polyclonal Antibody

53242 100ul
EUR 439

F2 Rabbit Polyclonal Antibody

53335 100ul
EUR 439

TH Rabbit Polyclonal Antibody

53432 100ul
EUR 439

MB Rabbit Polyclonal Antibody

53559 100ul
EUR 439

HP Rabbit Polyclonal Antibody

53811 100ul
EUR 439

Furthermore, transcriptome analysis showed that Wnt gene expression profiles at different stages of development, in adult tissues during regeneration siphon, in four different colors shell strain, and at this stage of development of colorless and colored in two different strains of shell color.