Predicting brain metastasis in early stage non-small cell lung cancer patients by gene expression profiling

Background: Non-small cell lung cancer (NSCLC) is the most common cause of cancer-deaths due to early metastatic spread, in many cases, especially to the brain. The pattern of the spread of disease-specific organ may be driven by the activity of specific signaling pathway in the primary tumor. We aim to identify gene expression signatures and the relevant signal associated with the development of brain metastasis (BM) after surgical resection of NSCLC.


Methods: frozen Fast NSCLC surgical specimens obtained from the tumor bank. RNA was extracted and analyzed by RNA-sequencing (Illumina HiSeq 2500). clinical parameters and gene expression examined to distinguish between patients with BM, patients with metastasis to sites other than the brain, and patients who do not develop metastatic disease in a significant clinical follow-up. Study component analysis and principal enrichment lines do.


Results: A total of 91 patients were included in this study, 32 of which were developed BM. The stage of disease at diagnosis (P = 0.004) and the degree of differentiation (P = 0.007) were significantly different between BM and control groups. We identified a set of 22 genes that are associated specifically with the BM, and not with metastasis to other sites. This sets reached 93.4% accuracy (95% CI: 86.2 to 97.5%), 96.6% specificity and 87.5% sensitivity of identifying the correct patient BM in the analysis of the internal validation leave-one-out , The oxidative phosphorylation pathway was highly correlated with the risk of BM.


Conclusion:
The expression level of a small set of genes from the primary tumor was found to predict the development of BM, clear of metastasis to other organs. Oxidative phosphorylation correlated genes and pathways require further validation as a useful predictor of the clinical potential of BM and perhaps as a new therapeutic target for the prevention of BM.

Predicting brain metastasis in early stage non-small cell lung cancer patients by gene expression profiling
Predicting brain metastasis in early stage non-small cell lung cancer patients by gene expression profiling

Gene expression profile identifies Zac1 role in metastatic cervical cancer

Zinc-finger proteins that regulate apoptosis and cell cycle arrest 1 (Zac1), encoded by the gene Plagl1, is a transcription factor of seven zinc-finger-containing belong printed genome and is expressed in various types of human embryonic and adult tissue. Zac1 is postulated be a tumor suppressor by inducing cell cycle arrest and apoptosis through interacting and modulating the transcriptional activity of p53 as named.

Correspondingly, reduction or loss of expression Zac1 associated with the occurrence and development of some human tumors, including cervical cancer, breast cancer, ovarian cancer, pituitary tumors and basal cell carcinoma, implying rationality of utilizing the expression Zac1 as a biomarker novel for evaluating the prognosis of cervical cancer.

However, until now, has not been clarified whether Zac1 expression associated with the prognosis of patients in clinical cervical cancer tumor samples. To answer the questions outlined above, we report here a comprehensive investigation Zac1 expression in biopsies of cervical carcinoma clinical. By analyzing the expression Zac1 in a variety of gene expression profiling of cervical cancer database, we demonstrated an association between high Zac1 expression and poor prognosis of cervical cancer.

RUSC1 Polyclonal Antibody

28956 100ul
EUR 439

Polyclonal RUSC1 Antibody

APR13173G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RUSC1 . This antibody is tested and proven to work in the following applications:

RUSC1 Polyclonal Conjugated Antibody

C28956 100ul
EUR 476.4

Rabbit Polyclonal RUSC2 Antibody

TA319794 100 µg Ask for price

Rabbit Polyclonal RUSC2 Antibody

TA319795 100 µg Ask for price

RUSC1 Polyclonal Antibody, HRP Conjugated

A60753
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

RUSC1 Polyclonal Antibody, FITC Conjugated

A60752
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

RUSC1 Polyclonal Antibody, Biotin Conjugated

A60751
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

RUSC2 (N-term) rabbit polyclonal antibody, Aff - Purified

AP53771PU-N 400 µl Ask for price

Rabbit Anti Human RUSC1 Polyclonal Antigen Affinity Purified (PBS with 0.05% sodium azide and 40% Glycerol, pH7.4) (IHC,ELISA)

IRBAHURUSC1AAP38120UL each
EUR 240
Description: Rabbit Anti Human RUSC1 Polyclonal Antigen Affinity Purified (PBS with 0.05% sodium azide and 40% Glycerol, pH7.4) (IHC,ELISA)

Rabbit Anti Human RUSC1 Polyclonal Antigen Affinity Purified (PBS with 0.05% sodium azide and 40% Glycerol, pH7.4) (IHC,ELISA)

IRBAHURUSC1AAP38200UL each
EUR 419
Description: Rabbit Anti Human RUSC1 Polyclonal Antigen Affinity Purified (PBS with 0.05% sodium azide and 40% Glycerol, pH7.4) (IHC,ELISA)

Rabbit Anti Human RUSC1 Polyclonal Antigen Affinity Purified (PBS with 0.05% sodium azide and 40% Glycerol, pH7.4) (IHC,ELISA)

IRBAHURUSC1AAP51120UL each
EUR 240
Description: Rabbit Anti Human RUSC1 Polyclonal Antigen Affinity Purified (PBS with 0.05% sodium azide and 40% Glycerol, pH7.4) (IHC,ELISA)

Rabbit Anti Human RUSC1 Polyclonal Antigen Affinity Purified (PBS with 0.05% sodium azide and 40% Glycerol, pH7.4) (IHC,ELISA)

IRBAHURUSC1AAP51200UL each
EUR 419
Description: Rabbit Anti Human RUSC1 Polyclonal Antigen Affinity Purified (PBS with 0.05% sodium azide and 40% Glycerol, pH7.4) (IHC,ELISA)

Rabbit Polyclonal Anti-RUSC1-AS1 Antibody

TA334977 100 µl Ask for price

Rabbit Anti Human RUSC1 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Immunofluorescence)

IRBAMLRUSC1AP09120UL each
EUR 320
Description: Rabbit Anti Human RUSC1 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Immunofluorescence)

Rabbit Anti Human RUSC1 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Immunofluorescence)

IRBAMLRUSC1AP09200UL each
EUR 530
Description: Rabbit Anti Human RUSC1 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Immunofluorescence)

RUSC1 Rabbit pAb

A15417-100ul 100 ul
EUR 369.6

RUSC1 Rabbit pAb

A15417-200ul 200 ul
EUR 550.8

RUSC1 Rabbit pAb

A15417-20ul 20 ul
EUR 219.6

RUSC1 Rabbit pAb

A15417-50ul 50 ul
EUR 267.6

RUSC1 Rabbit pAb

E2515417 100ul
EUR 225
Description: Available in various conjugation types.

RUSC2 Polyclonal Antibody

27844-100ul 100ul
EUR 302.4

RUSC2 Polyclonal Antibody

27844-50ul 50ul
EUR 224.4

RUSC2 Polyclonal Antibody

E912904 100ul
EUR 225
Description: Available in various conjugation types.

RUSC2 Polyclonal Antibody

27844 100ul
EUR 439

Polyclonal RUSC2 Antibody

AMM07697G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RUSC2 . This antibody is tested and proven to work in the following applications:

Polyclonal RUSC2 Antibody

AMM07698G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RUSC2 . This antibody is tested and proven to work in the following applications:

Polyclonal RUSC2 Antibody

AMM07699G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RUSC2 . This antibody is tested and proven to work in the following applications:

RUSC2 Polyclonal Conjugated Antibody

C27844 100ul
EUR 476.4

RUSC1 Antibody

24975-100ul 100ul
EUR 468

RUSC1 Antibody

5411-002mg 0.02 mg
EUR 206.18
Description: RUSC1 Antibody: RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IκB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-κB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-κB activation pathway.

RUSC1 Antibody

5411-01mg 0.1 mg
EUR 523.7
Description: RUSC1 Antibody: RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IκB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-κB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-κB activation pathway.

RUSC1 antibody

70R-20048 50 ul
EUR 522
Description: Rabbit polyclonal RUSC1 antibody

RUSC1 Antibody

1-CSB-PA871585LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against RUSC1. Recognizes RUSC1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

RUSC1 Antibody

1-CSB-PA020596GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against RUSC1. Recognizes RUSC1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

RUSC1 Antibody

E94571 100μg
EUR 255
Description: Available in various conjugation types.

RUSC1 Antibody

E308250 200ul
EUR 275
Description: Available in various conjugation types.

RUSC1 Antibody

DF16016-100ul 100ul
EUR 280

RUSC1 Antibody

DF16016-200ul 200ul
EUR 350

RUSC1 Antibody

DF16016 100ul
EUR 280
Description: Human,Mouse

RUSC1 Antibody

24975 100ul
EUR 479

RUSC1 Antibody (HRP)

20-abx311097
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

RUSC1 Antibody (FITC)

20-abx311098
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

RUSC1 Antibody (Biotin)

20-abx311099
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rabbit Polyclonal AntibodyPC1 Rabbit Polyclonal Antibody

53940 100ul
EUR 439

Rabbit Polyclonal AntibodyPC4 Rabbit Polyclonal Antibody

54946 100ul
EUR 439

Rabbit Polyclonal Anti-BAG4 rabbit polyclonal antibody

TA351743 100 µl Ask for price

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TA351758 100 µl Ask for price

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TA351848 100 µl Ask for price

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TA350234 100 µl Ask for price

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TA350419 100 µl Ask for price

Rabbit Polyclonal Anti-STX7 rabbit polyclonal antibody

TA350469 100 µl Ask for price

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TA350470 100 µl Ask for price

Rabbit Polyclonal Anti-SMYD5 rabbit polyclonal antibody

TA351731 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV5 rabbit polyclonal antibody

TA351861 100 µl Ask for price

Rabbit Polyclonal Anti-TRPV3 rabbit polyclonal antibody

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Rabbit Polyclonal Anti-SPARC rabbit polyclonal antibody

TA349441 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM3 rabbit polyclonal antibody

TA350251 100 µl Ask for price

Rabbit Polyclonal Anti-OLFM4 rabbit polyclonal antibody

TA350252 100 µl Ask for price

Rabbit Polyclonal Anti-ROBO4 rabbit polyclonal antibody

TA350367 100 µl Ask for price

Rabbit Polyclonal Anti-RRAGA rabbit polyclonal antibody

TA350374 100 µl Ask for price

Rabbit Polyclonal Anti-SAMD7 rabbit polyclonal antibody

TA350388 100 µl Ask for price

Rabbit Polyclonal Anti-SEPP1 rabbit polyclonal antibody

TA350395 100 µl Ask for price

Rabbit Polyclonal Anti-SENP8 rabbit polyclonal antibody

TA350399 100 µl Ask for price

Rabbit Polyclonal Anti-SENP5 rabbit polyclonal antibody

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Rabbit Polyclonal Anti-SMYD3 rabbit polyclonal antibody

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Rabbit Polyclonal Anti-SMYD4 rabbit polyclonal antibody

TA350429 100 µl Ask for price

Rabbit Polyclonal Anti-SNAI3 rabbit polyclonal antibody

TA350430 100 µl Ask for price

Rabbit Polyclonal Anti-STX18 rabbit polyclonal antibody

TA350473 100 µl Ask for price

Rabbit Polyclonal Anti-STX11 rabbit polyclonal antibody

TA350476 100 µl Ask for price

Rabbit Polyclonal Anti-STX19 rabbit polyclonal antibody

TA350477 100 µl Ask for price

Rabbit Polyclonal Anti-TBX18 rabbit polyclonal antibody

TA350485 100 µl Ask for price

Rabbit Polyclonal Anti-TBX10 rabbit polyclonal antibody

TA350486 100 µl Ask for price

Rabbit Polyclonal Anti-EFNB3 rabbit polyclonal antibody

TA350660 100 µl Ask for price

Rabbit Polyclonal Anti-FOXG1 rabbit polyclonal antibody

TA350672 100 µl Ask for price

Rabbit Polyclonal Anti-CERS3 rabbit polyclonal antibody

TA351342 100 µl Ask for price

Rabbit Polyclonal Anti-LLGL2 rabbit polyclonal antibody

TA351357 100 µl Ask for price

Rabbit Polyclonal Anti-PSMB8 rabbit polyclonal antibody

TA351358 100 µl Ask for price

Rabbit Polyclonal Anti-LONP1 rabbit polyclonal antibody

TA351359 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL2 rabbit polyclonal antibody

TA351360 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL3 rabbit polyclonal antibody

TA351362 100 µl Ask for price

Rabbit Polyclonal Anti-LOXL4 rabbit polyclonal antibody

TA351363 100 µl Ask for price

Rabbit Polyclonal Anti-LZTS1 rabbit polyclonal antibody

TA351367 100 µl Ask for price

Rabbit Polyclonal Anti-MACC1 rabbit polyclonal antibody

TA351368 100 µl Ask for price

Rabbit Polyclonal Anti-SLC7A5 rabbit polyclonal antibody

TA351714 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT6 rabbit polyclonal antibody

TA351863 100 µl Ask for price

Rabbit Polyclonal Anti-PRSS50 rabbit polyclonal antibody

TA351865 100 µl Ask for price

Rabbit Polyclonal Anti-PTPMT1 rabbit polyclonal antibody

TA350308 100 µl Ask for price

Rabbit Polyclonal Anti-DHCR24 rabbit polyclonal antibody

TA350394 100 µl Ask for price

Rabbit Polyclonal Anti-SEMA4A rabbit polyclonal antibody

TA350396 100 µl Ask for price

Rabbit Polyclonal Anti-TRIM21 rabbit polyclonal antibody

TA350447 100 µl Ask for price

Rabbit Polyclonal Anti-STXBP4 rabbit polyclonal antibody

TA350474 100 µl Ask for price

Rabbit Polyclonal Anti-LTB4R2 rabbit polyclonal antibody

TA351366 100 µl Ask for price

Rabbit Polyclonal Anti-AGPAT9 rabbit polyclonal antibody

TA351369 100 µl Ask for price

Rabbit Polyclonal Anti-MAGEB2 rabbit polyclonal antibody

TA351371 100 µl Ask for price

Rabbit Polyclonal Anti-SLC16A9 rabbit polyclonal antibody

TA351677 100 µl Ask for price

Rabbit Polyclonal Anti-SLC24A6 rabbit polyclonal antibody

TA351684 100 µl Ask for price

Rabbit Polyclonal Anti-SLC17A1 rabbit polyclonal antibody

TA351718 100 µl Ask for price

Rabbit Polyclonal Anti-S100A14 rabbit polyclonal antibody

TA350383 100 µl Ask for price

Rabbit Polyclonal Anti-SH3KBP1 rabbit polyclonal antibody

TA350412 100 µl Ask for price

Rabbit Polyclonal Anti-MAGEA11 rabbit polyclonal antibody

TA351370 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB1 rabbit polyclonal antibody

TA350405 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB6 rabbit polyclonal antibody

TA350406 100 µl Ask for price

Rabbit Polyclonal Anti-SERPINB8 rabbit polyclonal antibody

TA350407 100 µl Ask for price

Rabbit Polyclonal Anti-SIGLEC12 rabbit polyclonal antibody

TA350415 100 µl Ask for price

Rabbit Polyclonal Anti-SLC25A26 rabbit polyclonal antibody

TA350422 100 µl Ask for price

RUSC1 Antibody, HRP conjugated

1-CSB-PA871585LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against RUSC1. Recognizes RUSC1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

RUSC1 Antibody, FITC conjugated

1-CSB-PA871585LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against RUSC1. Recognizes RUSC1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACA06105-50UG - RUSC1 Antibody

OACA06105-50UG 50ug
EUR 179

RUSC1 Antibody, Biotin conjugated

1-CSB-PA871585LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against RUSC1. Recognizes RUSC1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACA06105-100UG - RUSC1 Antibody

OACA06105-100UG 100ug
EUR 319

Rabbit Polyclonal IR Antibody

TA325567 100 µl Ask for price

Rabbit Polyclonal GH Antibody

TA327684 1 ml Ask for price

Rabbit Polyclonal IR Antibody

TA327843 100 µl Ask for price

Rabbit Polyclonal GR Antibody

TA325748 100 µl Ask for price

Rabbit Polyclonal GR Antibody

TA325749 100 µl Ask for price

Rabbit Polyclonal GR Antibody

TA325750 100 µl Ask for price

Rabbit Polyclonal TK Antibody

TA325942 100 µl Ask for price

Rabbit polyclonal PC antibody

TA326111 100 µl Ask for price

TH Rabbit Polyclonal Antibody

53004 100ul
EUR 439

Rb Rabbit Polyclonal Antibody

53242 100ul
EUR 439

F2 Rabbit Polyclonal Antibody

53335 100ul
EUR 439

TH Rabbit Polyclonal Antibody

53432 100ul
EUR 439

MB Rabbit Polyclonal Antibody

53559 100ul
EUR 439

HP Rabbit Polyclonal Antibody

53811 100ul
EUR 439

XK Rabbit Polyclonal Antibody

53984 100ul
EUR 439

Rb Rabbit Polyclonal Antibody

54333 100ul
EUR 439

C7 Rabbit Polyclonal Antibody

54906 100ul
EUR 439

CP Rabbit Polyclonal Antibody

55277 100ul
EUR 439

Functional enrichment analysis showed that expression of high Zac1 associated with epithelial-mesenchymal transition (EMT), which was subsequently observed in clinical characteristics and metastatic carcinoma samples using immunohistochemical staining. Correspondingly, hypomethylation CpG islands in the promoter Zac1 observed in samples with high Zac1 expression in cervical carcinoma.