Xpc Antibody Rabbit
Lab Reagents
Human IgG antibody Laboratories manufactures the xpc antibody rabbit reagents distributed by Genprice. The Xpc Antibody Rabbit reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact rabbit Antibody. Other Xpc products are available in stock. Specificity: Xpc Category: Antibody Group: Rabbit
XPC siRNA |
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20-abx940004 | Abbexa |
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XPC siRNA |
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20-abx940005 | Abbexa |
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XPC Antibody, HRP conjugated |
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1-CSB-PA026217LB01HU | Cusabio |
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Description: A polyclonal antibody against XPC. Recognizes XPC from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
XPC Antibody, FITC conjugated |
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1-CSB-PA026217LC01HU | Cusabio |
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Description: A polyclonal antibody against XPC. Recognizes XPC from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
XPC Antibody, Biotin conjugated |
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1-CSB-PA026217LD01HU | Cusabio |
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Description: A polyclonal antibody against XPC. Recognizes XPC from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Anti-XPC (6D11) |
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YF-MA16082 | Abfrontier | 100 ug | EUR 363 |
Description: Mouse monoclonal to XPC |
XPC Polyclonal Antibody, Biotin Conjugated |
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A53793 | EpiGentek | 100 µg | EUR 570.55 |
Description: The best epigenetics products |
XPC Polyclonal Antibody, FITC Conjugated |
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A53794 | EpiGentek | 100 µg | EUR 570.55 |
Description: kits suitable for this type of research |
XPC Polyclonal Antibody, HRP Conjugated |
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A53795 | EpiGentek | 100 µg | EUR 570.55 |
Description: fast delivery possible |
Mouse Xpc ELISA KIT |
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ELI-17531m | Lifescience Market | 96 Tests | EUR 865 |
Human XPC ELISA KIT |
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ELI-40545h | Lifescience Market | 96 Tests | EUR 824 |
Mouse XPC shRNA Plasmid |
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20-abx973421 | Abbexa |
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Human XPC shRNA Plasmid |
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20-abx955132 | Abbexa |
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Xpc ORF Vector (Mouse) (pORF) |
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ORF061960 | ABM | 1.0 ug DNA | EUR 506 |
Xpc ORF Vector (Rat) (pORF) |
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ORF079210 | ABM | 1.0 ug DNA | EUR 506 |
XPC ORF Vector (Human) (pORF) |
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ORF035983 | ABM | 1.0 ug DNA | EUR 95 |
XPC ELISA Kit (Human) (OKCD01514) |
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OKCD01514 | Aviva Systems Biology | 96 Wells | EUR 792 |
Description: Description of target: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.114 ng/mL |